U-snRNPs which are a pivotal part of spliceosomes, are created between small non-coding nuclear RNAs and a protein moiety. Whereas the 7 Sm proteins are conserved, the RNP antigens are exclusive for each U-snRNP subclass.
RNP/Sm Bovine is purified from bovine tissues by proprietary protein-chemical techniques.
RNP/Sm Bovine is supplied in 20mM HEPES buffer pH-7.6, 250mM NaCl and 20% glycerol.
Avoid multiple freeze-thaw cycles.
Western blot with anti-RNP/Sm autoantibody positive sample.
1. Binds IgG type human auto antibodies.
2. Immunodot test with positive/negative samples.