prospec
PTPRN Human

PTPRN Human

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  • Description
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  • PTPRN Human

  • Protein Tyrosine Phosphatase Receptor Type N Human Recombinant
  • ENZ-1162
  • Shipped with Ice Packs

Catalogue number

ENZ-1162

Synonyms

Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512.

Introduction

Protein Tyrosine Phosphatase Receptor Type N (PTPRN) is a catalytically inactive protein and a major target of autoimmune response in diabetes mellitus. The long C-terminal intracellular tail covers the majority of autoantibody epitopes. PTPRN is expressed in neural, neuroendocrine and pancreatic islet cells.

Description

Recombinant Human Protein Tyrosine Phosphatase Receptor Type N produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 45kDa.
PTPRN is expressed with a 6xHis tag and purified by proprietary chromatographic techniques.

Source

Sf9 insect cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

PTPRN is supplied in 20mM HEPES buffer pH-7.5, 400mM NaCl and 20% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles.

Purity

Greater than 80.0% as determined by SDS-PAGE.

Immunological functions

1. Binds IgG-type human auto-antibodies.
2. immunodot test with positive/negative samples.

Applications

Western blot with patient sample.

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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