It has recently been identified that Omentin, also known as 34 kDa, is a fat deposition specific adipokine that has various interactions. In patients who are obese or have impaired glucose regulation, the concentrations of Omentin tend to be decreased, as well as with people who have diabetes (type 1 and 2) and in patients with polycystic ovary syndrome. Both of these diseases are commonly linked to insulin resistance within the body, in addition to obesity.
Studies have suggested that the link between Omentin with specific metabolic indexes may suggest that there is an elevation in levels of Omentin which is seen as being a marker for leanness. While a decreased level will underline possible outcomes with underlying issues such as obesity and related diseases, like diabetes, cancer, and cardiovascular disease. Something that scientists want to research in the future is the multiple roles that Omentin plays.
In medical research, adipose tissue is a point of high interest, partially because it’s an energy depot, but also because it produces more than 600 cytokines called adipokines. In humans, these are involved in various metabolic processes; this includes appetite regulation, how energy is expended, insulin sensitivity, cardiovascular activity, and inflammation.
Therefore, these could be markers of adipose tissue and increased metabolic risk. There is currently an ongoing search for adipokines that link obesity to related co-morbidities, and this has become a highly interesting topic in obesity research. As part of this work, there is an increasing need to define what function they have, what their molecular targets are, and what it is that makes them potentially clinically relevant as markers, and in the treatment of obesity and other metabolic diseases.
Adipose tissue is commonly known as body fat, and it accumulates mainly as subcutaneous and visceral fat. However, this tissue is also known for being a very important and incredibly active endocrine organ. It is well known that adipocytes (also known as fat cells) play a crucial role in the process of storing and releasing energy throughout the body. In more recent findings, the endocrine function that adipose has been discovered. What has been found is that in addition to adipocytes, adipose tissue also contains various cells that can create certain hormones as a response to signals sent by the rest of the body’s organs through Omentin - one of the newest adipokines.
It is through these hormones that adipose tissue plays a vital role in the body’s regulation of cholesterol, the metabolism of sex hormones and glucose. Studies have shown that prolonged accumulation of adipose tissue can lead to weight gain and obesity development, both of which are closely linked to a range of metabolic diseases, including hypertension, insulin resistance, and dyslipidemia. When it comes to obesity-related health problems, visceral obesity is thought to be the main risk factor for the development of most obesity-linked conditions. This concept is at a point of high medical interest because adipose tissue acts not only as a depot for energy but also produces nearly 600 cytokines that are involved in numerous metabolic processes.