prospec

HLA-DRA Human

  • Name
  • Description
  • Pricings
  • Quantity
  • HLA-DRA Human
  • Major Histocompatibility Complex Class II DR Alpha Human Recombinant
  • Shipped with Ice Packs

Catalogue number

PRO-1889

Synonyms

Major Histocompatibility Complex, Class II, DR Alpha, HLA-DRA1, MHC Class II AntigenDRA, MLRW, Histocompatibility AntigenHLA-DR Alpha, HLAClass II Histocompatibility Antigen, DR Alpha Chain, MHC Cell Surface Glycoprotein, HLA-DRA1.

Introduction

Major histocompatibility complex, class II, DR alpha (HLA-DRA) belongs to the MHC class II family. HLA-DRA binds peptides derived from antigens which access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for identification by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mainly by degradation of proteins which access the endocytic route, where they are processed by lysosomal proteases and other hydrolases.

Description

HLA-DRA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 212 amino acids (26-216 a.a) and having a molecular mass of 24.3kDa.
HLA-DRA is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

HLA-DRA protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.

Purity

Greater than 90% as determined by SDS-PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MIKEEHVIIQ AEFYLNPDQS GEFMFDFDGD EIFHVDMAKK ETVWRLEEFG RFASFEAQGA LANIAVDKAN LEIMTKRSNY TPITNVPPEV TVLTNSPVEL REPNVLICFI DKFTPPVVNV TWLRNGKPVT TGVSETVFLP REDHLFRKFH YLPFLPSTED VYDCRVEHWG LDEPLLKHWE FDAPSPLPET TE

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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