GSE, CD152, IDDM12, CELIAC3, CTLA-4.
Hamster Anti Mouse Monoclonal.
CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
mixture of mouse activated T cells.
Ion exchange column.
1mg/ml in PBS (after reconstitution).
Lyophilized: store at 4oC. After reconstitution, if not intended for use within a month, aliquot and store at -20oC.
Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Blocking and staining antibody. For staining, use for blocking CTLA-4 function should be determined by the investigator.
This antibody is only available as purified antibody.
Safety Data Sheet
Prospec's products are furnished for LABORATORY ESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.