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SARS MERS Spike S1 Antibody

SARS MERS Spike S1 Antibody

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  • SARS MERS Spike S1 Antibody

  • Mouse Anti SARS MERS Spike S1
  • ANT-766
  • Shipped with Ice Packs

Catalogue number

ANT-766

Type

Mouse antibody Monoclonal.

Introduction

SARS Coronavirus is an enveloped virus containing three outer structural proteins, namely the membrane (M), envelope (E), and spike (S) proteins. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. Accordingly, S-protein plays an important role in virus infection cycle and is the primary target of neutralizing antibodies.It has recently been shown that SARS is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness in humans, such as the common cold. Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). The first step in coronavirus infection is binding of the viral spike protein, a 139-kDa protein, to certain receptors on host cells. The spike protein is the main surface antigen of the coronavirus. The most prominent protein in the culture supernatants infected with SARS virus is a 46 kDa nucleocapsid protein. This suggests that the nucleocapsid protein is a major immunogen that may be useful for early diagnostics.

Description

SARS MERS Spike-S1 antibody is specific for the S1 domain of the spike protein of the MERS virus.

Formulation

1mg/ml in PBS and 0.1% NaN3.

Isotype

IgG1.

Physical Appearance

Sterile Filtered liquid formulation.

Purity

Greater than 90% as determined by SDS-PAGE gel.

Applications

ELISA.

Purification Method

Protein A affinity purified.

Stability

Store at 4°C, stable for 2 weeks. For long-term storage, store at -20°C.

Safety Data Sheet

Usage

Prospec's products are furnished for LABORATORY ESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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