prospec

CD31 Biotin Antibody

  • Name
  • Description
  • Pricings
  • Quantity
  • CD31 Biotin Antibody
  • CD31-Biotinylated, Mouse Anti Human
  • Shipped with Ice Packs

Catalogue number

ANT-053

Synonyms

Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, GPIIA', CD31 antigen, PECAM1, CD31.

Type

Mouse Anti Human Monoclonal.

Introduction

CD31 is a glycoprotein expressed on endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, fibroblasts, osteoclasts, neutrophils. In humans, the gene encoding CD31 is found on chromosome 17.
CD31 is a cluster of differentiation molecule. It is also called PECAM-1 for platelet endothelial cell adhesion molecule. It plays a key role in removing aged neutrophils from the body. Both the neutrophil and the macrophage express CD31 on their membranes, and during the testing process, these CD31 molecules bind the two cells together. If the neutrophil is healthy, it will send a signal to the macrophage, and the CD31 molecules will detach.
CD31 is also expressed in certain tumors, including epithelioid hemangioendothelioma, epithelioid sarcoma-like hemangioendothelioma, other vascular tumors, histiocytic malignancies, and plasmacytomas. It is rarely found in some sarcomas and carcinomas.

Clone

hCD31

Immunogen

Enriched human platelets

Ig Subclass

mouse IgG1

Purification Method

Protein A

Formulation

1mg/ml in PBS (after reconstitution).

Shipping Conditions

Antibody is shipped lyophilized at ambient temperature.

Storage Procedures

In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution,
if not intended for use within a month, aliquot and store at -20°C.

Solubility

Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

Applications

Flow cytometry, immunohistochemistry. For staining, use 10µl/106 cells.

Available Conjugates

This antibody is also available conjugated to FITC and biotin. For flow cytometry use 5-10µl/106 cells.

Note

CD31 is expressed in high levels on endothelial cells and in lower levels on monocytes, granulocytes and platelets.

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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