- Name
- Description
- Cat#
- Pricings
- Quantity
Catalogue number
ENZ-801
Synonyms
Caspase-2, CASP-2, CASP2, Caspase 2 Apoptosis-Related Cysteine Peptidase, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1, ICH1, NEDD2, Caspase-2 subunit p18, Caspase-2 subunit p13, Caspase-2 subunit p12, Caspase 2 isoform 1, PPP1R57.
Introduction
Caspase 2 Apoptosis-Related Cysteine Peptidase (CASP2) is a part of the cysteine-aspartic acid protease (caspase) family. CASP2 takes part in the activation cascade of caspases responsible for apoptosis execution. CASP2 is also responsible for inactivating proteins essential for cell survival. The proteolytic cleavage of CASP2 is induced by a variety of apoptotic stimuli.
Description
CASP2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 126 amino acids (348-452) and having a molecular mass of 14.1kDa.
CASP2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CASP2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
The CASP2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 80.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MAGKEKLPKM RLPTRSDMIC GYACLKGTAA MRNTKRGSWY IEALAQVFSE RACDMHVADM LVKVNALIKD REGYAPGTEF HRCKEMSEYC STLCRHLYLF PGHPPT.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.