Complement C2, C3/C5 convertase, C2.
C2 forms the proteolytic subunit of the C3 and C5 convertase of both pathways. Initiation of each pathway generates proteolytic enzyme complexes which binds to the target surface. C1s and MASP in these complexes activate both C4 and C2. They cleave a peptide bond in C4 depositing C4b on the surface and also cleave C2 into 2 fragments.
Human Complement C2 produced in Human plasma having a molecular mass of 93 kDa.
Sterile Filtered solution.
25mM sodium phosphate and 100mM NaCl, pH 6.0.
C2 Human is stable at 4°C if entire vial will be used within 2-4 weeks.Store, frozen below -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Greater than 95.0% as determined by SDS-PAGE.
Human Virus Test
Plasma from each donor has been tested and found negative for antibody to HIV-1,
HIV-2, HCV and HBSAG.