GSK3-beta interaction protein, GSKIP, C14orf129, HSPC210, MGC4945.
GSK3-beta interaction protein (C14orf129) is defined as a naturally occurring protein which is homologous with the GSK3beta interaction domain of Axin and is able to negatively regulate GSK3beta of the Wnt signaling pathway. C14orf129 may affect GSK3? activity on neurite outgrowth by inhibiting the specific phosphorylation of tau (ser396).
C14ORF129 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 159 amino acids (1-139 a.a.) and having a molecular mass of 17.8kDa.
The C14ORF129 is purified by proprietary chromatographic techniques.
The C14ORF129 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 50mM NaCl.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.