prospec

BRD2 Human

  • Name
  • Description
  • Pricings
  • Quantity
  • BRD2 Human
  • Bromodomain Containing 2 Human Recombinant
  • Shipped with Ice Packs

Catalogue number

PRO-2122

Synonyms

Bromodomain Containing 2, RING3, Really Interesting New Gene 3 Protein, Bromodomain-Containing 2, O27.1.1, FSRG1, Female Sterile Homeotic-Related Gene 1, Bromodomain-Containing Protein 2, KIAA9001, D6S113E, RNF3, FSH, NAT, Bromodomain-containing protein 2 .

Introduction

Bromodomain Containing 2, also known as BRD2 is a transcriptional regulator which is a member of the BET, bromodomains and extra terminal domain, family of roteins. BRD2 links with transcription complexes and it acetylated chromatin in the course of mitosis, and it selectively binds o the acetylated lysine-12 residue of histone H4 through its two romodomains. BRD2 maps to the major histocompatability complex  MHC) class II region on chromosome 6p21.3, however sequence comparison  advocate that the protein is not implicated in the immune response. BRD2 has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy which grows to be visible in adolescence.

Description

BRD2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 478 amino acids (1-455 a.a) and having a molecular mass of 52.8kDa.
BRD2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

BRD2 protein solution (1mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by SDS-PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSMLQNVTP HNKLPGEGNA GLLGLGPEAA APGKRIRKPS LLYEGFESPT MASVPALQLT PANPPPPEVS NPKKPGRVTN QLQYLHKVVM KALWKHQFAW PFRQPVDAVK LGLPDYHKII KQPMDMGTIK RRLENNYYWA ASECMQDFNT MFTNCYIYNK PTDDIVLMAQ TLEKIFLQKV ASMPQEEQEL VVTIPKNSHK KGAKLAALQG SVTSAHQVPA VSSVSHTALY TPPPEIPTTV LNIPHPSVIS SPLLKSLHSA GPPLLAVTAA PPAQPLAKKK GVKRKADTTT PTPTAILAPG SPASPPGSLE PKAARLPPMR RESGRPIKPP RKDLPDSQQQ HQSSKKGKLS EQLKHCNGIL KELLSKKHAA YAWPFYKPVD ASALGLHDYH DIIKHPMDLS TVKRKMENRD YRDAQEFAAD VRLMFSNCYK YNPPDHDVVA MARKLQDVFE FRYAKMPD.

Safety Data Sheet

Usage

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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