HDGF or Hepatoma-derived growth factor is known for its proliferative, angiogenic, and neurotrophic action, and plays a role in how cancer develops in certain cases and is a high mobility group protein.
What is the disease relevance of HDGF?
Studies have shown that HDGF is often more highly expressed in the lungs of people with dominant pulmonary fibrosis, mainly in the epithelial cells, rather than in control non-fibrotic lungs. This suggests that this protein - HDGF - many play a vital role in the development and progression over time of lung cancer.
HDGF has mitogenic activities for specific hepatoma cells, angiogenic activities via nuclear targeting, and fibroblasts and vascular smooth muscle cells. The relationship between HDGF expression and clinicopathological variables, in addition to the prognostic significance of HDGF in patients suffering from resected non-small-cell lung cancer. In contradiction to this, biopsies of melanoma showed that there were strong expressions of HDGF throughout the tumour, including in cells located deep within the dermis. What these findings suggest is that HDGF could be an important prognostic factor for pancreatic ductal carcinoma.
Chemical compound and disease
Studies have found that the hepatoma-derived growth factor was more strongly expressed in tumours that than they are in fatty liver mice than in cirrhotic liver of choline-deficient amino acid feeding rats. Bioassay of fast protein liquid chromatography fractions of extracted tissue identified a platelet-derived growth factor, heparin-binding epidermal factor, and hepatoma-derived growth factor in normal fibroid and myometrium tumours.
Biological context of HDGF
It has been shown that double immunostaining for endothelial cells with a growth factor that is transforming receptor antibody and BrdU working as a marker of cell proliferation, exogenous HDGF was able to selectively stimulate endothelial cell BrdU. It has been noted that adenoviral overexpression of HDGF was mitogenic for human pulmonary microvascular endothelial cells in a serum-free medium, increasing the chance of cell migration by double.
Anatomical context of HDGF
The chick chorioallantoic membrane, a biologic assay for angiogenesis, exogenous recombinant HDGF stimulated blood vessel formation and a reorganization of cells within the CAM, depending on dose, into a compact and more linear alignment reminiscent of tube formation.
Previously, HDGF was identified as a developmentally regulated cardiovascular and renal gene that has mitogenic properties for vascular smooth muscle and aortic endothelial cells. In vivo, intratracheal instillation of recombinant HDGF induced the proliferation of bronchial and alveolar epithelial cells without creating marked interstitial inflammation.
It has also been suggested that hepatoma-derived growth factor was secreted or released from the foci and caused the stimulation of hepatocyte proliferation in a paracrine manner in FLS mice, and caused stimulation of proliferation hepatic tumour cells in an autocrine manner.
Originally, the hepatoma-derived growth factor was identified as being a secreted mitogen from the human hepatoma cell line.
What is the association of HDGF with chemical compounds?
Expression in the PDT-resistant variants was downregulated for NNX3, human HepG2 3 region
Mboi complementary DNA, glutamate dehydrogenase, hepatoma-derived growth factor, and the mitochondrial genes coding for 16s ribosomal RNA protein.