Bone Morphogenetic Protein Receptor, Type IB, BMP Type-1B Receptor, EC 188.8.131.52, BMPR-1B, ALK6, Bone Morphogenetic Protein Receptor Type-1B, Serine/Threonine Receptor Kinase, CDw293 Antigen, EC 2.7.11, CDw293, ALK-6, Bone morphogenetic protein receptor type-1B.
Bone Morphogenetic protein Receptor-1B, also known as BMPR1B belongs to
the TKL Ser/Thr protein kinase family. BMPR1B is on ligand binding,
forms a receptor complex consisting of two type II and two type I transmembrane
serine/threonine kinases. Type II receptors phosphorylate as well as activate type I
receptors which autophosphorylate, afterward bind and activate SMAD
transcriptional regulators. BMPR1B is
receptor for BMP7/OP-1 as well as GDF5.
BMPR1B Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 136 amino acids (14-126 a.a) and
having a molecular mass of 15.1kDa.
BMPR1B is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Sterile Filtered colorless solution.
BMPR1B protein solution (0.5mg/ml) containing Phosphate
buffered saline (pH7.4), 20% glycerol, 1mM DTT and 0.1mM PMSF.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Greater than 80.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEED
DSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD GPIHHR.
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