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VZV is closely related to the herpes simplex viruses(HSV), sharing much genomehomology. The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV, however there is no equivalent of HSV gD. VZV virons are spherical and 150-200 nm in diameter. Their lipidenvelope encloses the nucleocapsid of 162 capsomeres arranged in a hexagonalform. Its DNAis a single, linear, double-stranded molecule, 125,000 nt long. The virus is very susceptible to disinfectants, notably sodium hypochlorite. Within the body it can be treated by a number of drugs and therapeutic agents including aciclovir, zoster-immune globulin(ZIG), and vidarabine.
The E.Coli derived recombinant protein contains the VZV ORF26 immunodominant regions, amino acids 9-33, 184-208.
Varicella was purified by proprietary chromatographic technique.
Varicella protein is >95% pure as determined by 10% PAGE (coomassie staining).
25mM Tris-Hcl pH 8.0, 1mM EDTA and 50% glycerol.
Varicella protein is shipped at ambient temperature. Upon arrival, Store at -20°C.
Five years frozen. One month in solution at room temperature.
Immunoreactive with sera of VZV-infected individuals.
Varicella Zoster antigen is suitable for ELISA and Western blots, excellent antigen for detection of VZV with minimal specificity problems.
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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