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Protein Catalog >> Growth Factors >> TGF b 1 Human Recombinant
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Transforming Growth Factor-Beta 1 Human Recombinant
Catalogue Number CYT-716
Synonyms Transforming growth factor beta-1, TGF-beta-1, CED, DPD1, TGFB, TGF-b 1, LAP, TGFB1.
Introduction Transforming growth factor betas (TGFBetas) mediate many cell-cell interactions that occur during embryonic development. Three TGFBetas have been identified in mammals. TGFBeta1, TGFBeta2 and TGFBeta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.
Description TGFB1 Human Recombinant produced in Human 293 cells is a glycosylated homodimeric polypeptide chain containing 2 x 112 amino acids and having a total molecular mass of 25.6kDa. The TGFB1 is purified by proprietary chromatographic techniques.
Source Human 293 cells.
Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder.
Lyophilized from a sterile filtered solution containing 50mM Glycine, 50mM sodium chloride, 10% Trehalose and BSA (4:1 protein to BSA ratio) pH 4.0.
Solubility It is recommended to reconstitute the lyophilized TGFB1 in sterile 10mM Acetic Acid at a concentration of 0.1 mg/ml, which can then be further diluted to other aqueous solutions.
Stability Lyophilized TGFB1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TGFB1 Human should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity Greater than 95.0% as determined by SDS-PAGE.
Biological Activity The ED50 as determined by the dose-dependent inhibition of IL-4-induced proliferation of mouse HT-2 cells is less than 0.05ng/ml, corresponding to a specific activity of 2x107units/mg.
References 1.Title:Imatinib attenuates skeletal muscle dystrophy in mdx mice .
Publication:Published online before print March 16, 2009, doi: 10.1096/fj.09-129833 August 2009 The FASEB Journal vol. 23 no. 8 2539-2548 .

2.Title:Characterization of Non-Specific Cytotoxic Cell Receptor Protein 1: A New Member of the Lectin-Type Subfamily of F-Box Proteins.
Publication:Kallio H, Tolvanen M, J?nis J, Pan P-w, Laurila E, et al. (2011) Characterization of Non-Specific Cytotoxic Cell Receptor Protein 1: A New Member of the Lectin-Type Subfamily of F-Box Proteins. PLoS ONE 6(11): e27152. doi:10.1371/journal.pone.0027152

3.Title: Cancer-Associated Carbonic Anhydrases IX and XII: Effect of Growth Factors on Gene Expression in Human Cancer Cell Lines.
Publication: Journal of Cancer Molecules 5(3): 73-78, 2010.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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