Synovial Sarcoma, X Breakpoint

Synovial Sarcoma, X Breakpoint

Synovial Sarcoma, X Breakpoint

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  • View Data Sheet

    Description:

    Synovial Sarcoma, X Breakpoint 2 Human Recombinant

    Cancer/testis antigen family 5, member 2b, CT5.2b, Protein SSX2, Cancer/testis antigen 5.2, Synovial sarcoma, X breakpoint 2, CT5.2, Tumor antigen HOM-MEL-40, SSX2, SSX2A, SSX2B.

    Product # :

    PRO-1996

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    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    SSX2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-188a.a) and having a molecular mass of 24.0kDa. SSX2 is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    SSX2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.

    Purity

    Greater than 85.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Synovial Sarcoma, X Breakpoint 2 (SSX2) is a part of the family of highly homologous synovial sarcoma X breakpoint proteins which play a role as transcriptional repressors. Homologous synovial sarcoma X breakpoint proteins are also able to bring out spontaneous humoral and cellular immune responses in cancer patients, and are effective targets in cancer vaccine-based immunotherapy.

    • Synonyms

      Cancer/testis antigen family 5, member 2b, CT5.2b, Protein SSX2, Cancer/testis antigen 5.2, Synovial sarcoma, X breakpoint 2, CT5.2, Tumor antigen HOM-MEL-40, SSX2, SSX2A, SSX2B.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH RSMNGDDAFA RRPTVGAQIP EKIQKAFDDI AKYFSKEEWE KMKASEKIFY VYMKRKYEAM TKLGFKATLP PFMCNKRAED FQGNDLDNDP NRGNQVERPQ MTFGRLQGIS PKIMPKKPAE EGNDSEEVPE ASGPQNDGKE LCPPGKPTTS EKIHERSGPK RGEHAWTHRL RERKQLVIYE EISDPEEDDE.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Ssx2 Human
  • View Data Sheet

    Description:

    Synovial Sarcoma, X Breakpoint 1 Human Recombinant

    Synovial Sarcoma X Breakpoint 1, Cancer/Testis Antigen 5.1, CT5.1, SSRC Sarcoma Synovial X-Chromosome-Related 1, Cancer/Testis Antigen Family 5 Member 1, Cancer/Testis Antigen Family 5, Protein SSX1, Member 1, SSX1.

    Product # :

    PRO-1379

    Price :

    Quantity :

    Shipping Method :

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    Shipped with Ice Packs

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    More Info

    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    SSX1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (1-188 a.a) and having a molecular mass of 24.3kDa.SSX1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    SSX1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

    Purity

    Greater than 85.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Synovial Sarcoma, X Breakpoint 1 (SSX1) is a member of a family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. SSX proteins are localized to the nucleus and expressed in testis and some types of cancers and, hence, they are classified as C/T (cancer/testis) antigens. These proteins may serve as transcriptional repressors. SSX1 genes are involved in the t (X;18) translocation typically found in all synovial sarcomas. This translocation leads to the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. These hybrid proteins are most likely responsible for transforming activity.

    • Synonyms

      Synovial Sarcoma X Breakpoint 1, Cancer/Testis Antigen 5.1, CT5.1, SSRC Sarcoma Synovial X-Chromosome-Related 1, Cancer/Testis Antigen Family 5 Member 1, Cancer/Testis Antigen Family 5, Protein SSX1, Member 1, SSX1.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMNGDDTF AKRPRDDAKA SEKRSKAFDD IATYFSKKEW KKMKYSEKIS YVYMKRNYKA MTKLGFKVTL PPFMCNKQAT DFQGNDFDND HNRRIQVEHP QMTFGRLHRI IPKIMPKKPA EDENDSKGVS EASGPQNDGK QLHPPGKANI SEKINKRSGP KRGKHAWTHR LRERKQLVIY EEISDPEEDD E.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Ssx1 Human

About SSX / Synovial Sarcoma, X Breakpoint:

Synovial sarcoma is a rare type of cancer that occurs in the joints, muscles and other soft tissues. It is characterized by an abnormal growth of immature cells in the lining of the joint cavity called synovium. The main characteristic that distinguishes synovium from other types of cancers is its location inside a joint where it replaces normal tissue. Synovial sarcoma can be divided into two categories: high-grade (aggressive) or low-grade (slow-growing). There are currently no screening tests for synovial sarcoma, but treatment options are available to help control this condition.

SSX Function
The X Breakpoint or GC SSX2 gene causes Synovial Sarcoma at least 5% of the time and is prevalent in young people aged 12-30 years old. This gene causes cells to divide more rapidly than usual, which leads to an abnormal accumulation of cells within a joint or muscle. It can also make the surrounding area inflamed, causing pain.

Synovial Sarcoma, X Breakpoint Mechanism
Like other cancers caused by genetic changes, this condition starts when something goes wrong with the DNA inside cells’ nucleus that makes them not function properly anymore; these mistakes are called mutations, and they affect genes on chromosomes 17 and 22 as well as chromosome X in men (women have two copies of each X chromosome). The resulting imbalance deregulates cell growth leading it to grow abnormally fast out of control, ultimately causing cancerous tumors to grow throughout soft tissues. These mutations occur randomly and are not inherited but can be passed on to other generations if a mutation is found in the germline cells (egg or sperm).