Streptokinase | ProSpec

Description

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Quantity

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Streptokinase Recombinant

	250,000IU($210)
	750,000IU($400)
	1.5MIU($725)

Catalogue Number

ENZ-315

Synonyms

Streptokinase, SK.

Introduction

Streptokinase is an extracellular metallo-enzymeproduced by beta-haemolytic streptococcusand is used as an effective and cheap clot-dissolving medicationin some cases of myocardial infarction(heart attack) and pulmonary embolism.
It belongs to a group of medications known as fibrinolytics, and works by activating plasminogenthrough cleavage to produce plasmin.

Description

Streptokinase Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 414 amino acids and having a molecular weight of 47 kd.
The Streptokinase is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

The protein (1.5 MIU) was lyophilized from a sterile solution containing 12.5 mg HSA, 2.3 mg Sodium phosphate dibasic, 0.55 mg sodium phosphate monobasic buffer and 4.2 mg Sodium glutamate monohydrate.

Solubility

It is recommended to reconstitute the lyophilized Streptokinase in sterile 18MΩ-cm H2O.

Stability

Lyophilized Streptokinase although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Streptokinase should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

Purity

Greater than 98.0% as determined by(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Biological Activity

One unit will liquify a standard clot of fibrinogen, plasminogen and thrombin at pH7.5 at 37°C in 10 min.

Usage

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.