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Protein Catalog >> Chemokines >> PF 4 Human
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Platelet Factor-4 Human (CXCL4)
 
Catalogue Number CHM-234
Synonyms CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.
Introduction Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
Description Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues.
Source Human Platelets.
Physical Appearance Sterile Filtered white lyophilized powder.
Formulation The CXCL4 protein was lyophilized in PBS buffer pH-7.4.
Solubility It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C.
Please prevent freeze-thaw cycles.
Purity Greater than 95.0% as determined by(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Amino acid sequence The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu.
Activity Control Binding of HIT-antibodies.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.
Related Products
» CXCL4 Variant 1 Human
» PF 4 Human
» PF 4 Mouse
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