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Catalogue Number
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ENZ-423
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Synonyms
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DPRA, NFSB, NFSI, NTR.
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Introduction
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NFNB demonstrates the capability to reduce quinines. NFNB enzyme activates prodrugs in antibody directed enzyme prodrug therapy. NFNB reduces nitrofurazone, quinones and anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.
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Description
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NFNB Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-217 a.a.) and having a molecular mass of 26 kDa. The NFNB is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
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Source
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Escherichia Coli.
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Physical Appearence
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Sterile filtered colorless solution.
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Formulation
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1mg/ml solution containing 20mM Tris pH-8, 1mM DTT, 0.05M NaCl & 10% glycerol.
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Stability
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NFNB Human although stable at 4C for 1 week, should be stored desiccated
below -18C. Please prevent freeze thaw cycles.
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Purity
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Greater than 95.0% as determined by SDS-PAGE.
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Amino Acid Sequence
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MGSSHHHHHH SSGLVPRGSH MDIISVALKR HSTKAFDASK KLTPEQAEQI KTLLQYSPSS TNSQPWHFIV ASTEEGKARV AKSAAGNYVF
NERKMLDASH VVVFCAKTAM DDVWLKLVVD QEDADGRFAT PEAKAANDKG RKFFADMHRK DLHDDAEWMA KQVYLNVGNF LLGVAALGLD AVPIEGFDAA ILDAEFGLKE KGYTSLVVVP VGHHSVEDFN ATLPKSRLPQ NITLTEV.
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Usage
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ProSpec''s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Related Products
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Website : www.prospecbio.com
Email: info@prospecbio.com |
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