Myostatin Propeptide Human

Description

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Quantity

Shipping

Myostatin Propeptide Human Recombinant

	5µg($50)
	25µg($130)
	1mg($4680)

Catalogue Number

CYT-448

Synonyms

GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy.

Introduction

Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.

Description

Recombinant Human Myostatin Propeptide is a 27.8 kDa protein containing 244 amino acid residues of the human Myostatin Propeptide.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered white lyophilized (freeze-dried) powder.

Formulation

Lyophilized from 10mM Acetic Acid.

Solubility

It is recommended to reconstitute the lyophilized Myostatin Propeptide in sterile 50mM Acetic Acid at 0.1 mg/ml, which can then be further diluted to other aqueous solutions.

Stability

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time.

Purity

Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Amino Acid Sequence

MNENSEQKE NVEKEGLCNA CTWRQNTKSS RIEAIKIQIL SKLRLETAPN ISKDVIRQLL PKAPPLRELI DQYDVQRDDS SDGSLEDDDY HATTETIITM PTESDFLMQV DGKPKCCFFK FSSKIQYNKV VKAQLWIYLR PVETPTTVFV QILRLIKPMK DGTRYTGIRS LKLDMNPGTG IWQSIDVKTV LQNWLKQPES NLGIEIKALD ENGHDLAVTF PGPGEDGLNP FLEVKVTDTP KRSRR.

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.