|
|
|
|
|
|
|
|
|
|
|
|
|
Catalogue Number
|
ANT-235
|
|
Synonyms
|
MYC, CMYC, C-MYS, V-MYC, P64.
|
|
Type
|
Polyclonal Rabbit Antibody.
|
|
Introduction
|
c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of c-Myc have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
|
|
Clone
|
PPMYCSHG.
|
|
Description
|
Polyclonal antibodies are produced by immunizing rabbits with synthetic peptide (EQKLISEEDL) coupled to KLH.
|
|
Formulation
|
Serum with 0.02% sodium azide.
|
|
Stability / Shelf Life
|
2 years at -20°C. 1 month at 4°C.
|
|
Dilution
|
Western Blotting: 1:500.
|
|
Applications
|
Western Blot, Immunoprecipitation.
|
|
Usage
|
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
|
|
Related Products
|
|
|
|
|
|
|
| Contact Us |
 |
Toll Free Phone: 1-(866)-245-0885
Toll Free Fax: 1-(866)-796-4944
Postal Address: PO Box 6591,
East Brunswick, 08816 NJ |
 |
Toll Free Phone: 00-800-800-66666
Toll Free Fax: 00-800-800-67890 |
 |
International Phone: +972-8-9471175
International Fax: +972-8-9460534
Postal Address: PO Box 4157,
Ness-Ziona, 74140 Israel
|
|
 |
Website : www.prospecbio.com
Email: info@prospecbio.com |
|
|
|
|
|
|
|