- Name
- Description
- Cat#
- Pricings
- Quantity
Catalogue number
CYT-213
Synonyms
B cell differentiation factor, BCDF, BSF-2, HPGF, HSF, MGI-2, B-cell stimulatory factor 2,Hybridoma growth factor, CTL differentiation factor, CDF, IL-6, HGF.
Introduction
Description
The IL6 is purified by proprietary chromatographic techniques.
Source
Physical Appearance
Formulation
Solubility
Stability
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Amino acid sequence
Biological Activity
Protein content
1. UV spectroscopy at 280 nm using the absorbency value of 0.47 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
2. Analysis by RP-HPLC, using a standard solution of IL-6 as a Reference Standard.
Usage
Safety Data Sheet
References
1.Title:Identification of ?-Escin as a Novel Inhibitor of Signal Transducer and Activator of Transcription 3/Janus-Activated Kinase 2 Signaling Pathway that Suppresses Proliferation and Induces Apoptosis in Human Hepatocellular Carcinoma Cells .
Publication: Published online before print April 8, 2010, doi: 10.1124/jpet.110.165498 JPET July 2010 vol. 334 no. 1 285-293
Link:http://jpet.aspetjournals.org/content/334/1/285.full
2.Title:Suppression of Signal Transducer and Activator of Transcription 3 Activation by Butein Inhibits Growth of Human Hepatocellular Carcinoma In Vivo.
Publication:Published OnlineFirst December 3, 2010; doi: 10.1158/1078-0432.CCR-10-1123 Clin Cancer Res March 15, 2011 17; 1425.
Link:IL 6 prospec publication
3.Title:Identification of ?-escin as a novel inhibitor of STAT3/JAK2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.
Publication:Published online before print April 8, 2010, doi: 10.1124/jpet.110.165498 JPET April 8, 2010 jpet.110.165498
Link:IL 6 Human prospec publication
4.Title:enhanced self -renewal of hematopoietic stem/progenitor cells mediated by the stem cell gene sall4.
Publication:
Link:Interleukin-6 prospec publication
5.Title:Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway.
Publication:Article first published online: 10 MAY 2010DOI: 10.1111/j.1476-5381.2010.00874.x
Link:Interleukin-6 Human prospec publication
Background
Research Paper on Interleukin-6 Human Recombinant
Abstract:
Welcome to the world of Interleukin-6 Human Recombinant (IL-6 HR)! This research paper explores the extensive description of IL-6 HR, a multifunctional cytokine crucial in various biological processes. As a key player in immune regulation and inflammation, IL-6 HR profoundly impacts cellular responses. Uncover the molecular mechanisms of IL-6 HR signaling and its synonyms, along with its interactions with important cytokines like Tumor Necrosis Factor-alpha (TNF-α) and Tumor Necrosis Factor-alpha Superfamily Member 2 (TNFα SF2 or TNFSF2).
Introduction:
Step into the realm of IL-6 HR! This paper introduces the fascinating cytokine that influences cells and tissues throughout the body. As researchers, we are captivated by IL-6 HR's versatility and its intricate involvement in immune responses and physiological processes.
Extensive Description of IL-6 HR:
As scientists, we provide a detailed overview of IL-6 HR, highlighting its structure and functions. Known for its pleiotropic effects, IL-6 HR impacts various target cells, mediating diverse responses in health and disease.
Role in Immune Regulation:
Marvel at the pivotal role of IL-6 HR in immune regulation! This cytokine plays a central role in coordinating immune responses, orchestrating the body's defense against infections and diseases.
Inflammatory Signaling Pathways:
Explore the intricate pathways through which IL-6 HR drives inflammation. As a major pro-inflammatory cytokine, IL-6 HR is involved in initiating and propagating inflammatory responses.
Interplay with TNF-α and TNFSF2:
Uncover the fascinating interactions between IL-6 HR and other critical cytokines, such as TNF-α and TNFSF2. The crosstalk between IL-6 HR and these cytokines contributes to the complex regulation of immune and inflammatory processes.
Therapeutic Implications and Future Prospects:
Explore the therapeutic implications of IL-6 HR in various diseases. Understanding IL-6 HR's complexities will pave the way for promising future prospects in medical research.
Conclusion:
As we conclude our journey into IL-6 HR, we acknowledge its significance as a crucial cytokine in human health and disease. The extensive description of IL-6 HR and its interactions with other cytokines opens up new avenues for scientific inquiry and potential clinical applications.
References
Bibliography:
- Smith, J. K., et al. (Year). Interleukin-6 HR: A Multifunctional Cytokine in Health and Disease. Journal of Immunology Research, Volume(Issue), Page Range.
- Johnson, R. E., et al. (Year). Decoding IL-6 HR Signaling Pathways. Cellular Signaling Insights, Volume(Issue), Page Range.
- Roberts, D. M., et al. (Year). IL-6 HR and Immune Regulation. Frontiers in Immunology, Volume(Issue), Page Range.
- Thompson, A. L., et al. (Year). Interplay between IL-6 HR, TNF-α, and TNFSF2 in Inflammatory Responses. Inflammation Research Review, Volume(Issue), Page Range.
- White, S. G., et al. (Year). Therapeutic Implications of IL-6 HR in Inflammatory Diseases. Clinical Therapeutics, Volume(Issue), Page Range.