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Catalogue Number
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HIV-115
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Introduction
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Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
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Description
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E.coli derived recombinant 56kDa protein, (Purified/Coating; EIA), strain: BL21 DE3(2B3A).
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Purification Method
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HTLV-I+II was purified by proprietary chromatographic technique.
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Purity
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Protein is >95% pure as determined by SDS-PAGE.
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Physical Appearance
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Sterile Filtered clear solution.
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Formulation
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(1mg/ml) 25mM Tris, 250mM Glycine and 0.1% SDS.
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Stability
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Protein is shipped at ambient temperature. Upon arrival, Store at -20°C.
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Applications
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Use as an antigen in ELISA and Western Blots.
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Usage
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ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Related Products
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| Contact Us |
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Toll Free Phone: 1-(866)-245-0885
Toll Free Fax: 1-(866)-796-4944
Postal Address: PO Box 6591,
East Brunswick, 08816 NJ |
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Toll Free Phone: 00-800-800-66666
Toll Free Fax: 00-800-800-67890 |
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International Phone: +972-8-9471175
International Fax: +972-8-9460534
Postal Address: PO Box 4157,
Ness-Ziona, 74140 Israel
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Website : www.prospecbio.com
Email: info@prospecbio.com |
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