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Catalogue Number
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HIV-144
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Introduction
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Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
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Description
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The E.Coli derived recombinant mosaic protein contains the gp21 and gp46 immunodominant regions, 374-400 amino acids and 190-207 amino acids, the MW is 42kDa. The protein is fused with GST at N-terminus.
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Purification Method
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HTLV-1 Mosaic was purified by proprietary chromatographic technique.
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Purity
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HTLV-1 Mosaic protein is >95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.
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Formulation
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60mM NaCl, 50mM Tris-HCl pH 8.0, 0.25% Sarkosil, 50% glycerol and 10mM glutathione.
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Storage
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HTLV-1 Mosaic although stable at 4°C for 1 week, should be stored below -18°C.
Please prevent freeze thaw cycles.
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Specificity
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Immunoreactive with all sera of HTLV-I and HTLV-II infected individuals with antibody response to HTLV envelope.
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Applications
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HTLV-1 Mosaic can be used as an antigen in ELISA and Western Blots. Excellent reagent for correct detection of HTLV infections, with minimal specificity problems.
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Usage
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ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Related Products
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| Contact Us |
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Toll Free Phone: 1-(866)-245-0885
Toll Free Fax: 1-(866)-796-4944
Postal Address: PO Box 6591,
East Brunswick, 08816 NJ |
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Toll Free Phone: 00-800-800-66666
Toll Free Fax: 00-800-800-67890 |
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International Phone: +972-8-9471175
International Fax: +972-8-9460534
Postal Address: PO Box 4157,
Ness-Ziona, 74140 Israel
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Website : www.prospecbio.com
Email: info@prospecbio.com |
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