HTLV-1 mosaic
HTLV-1 Mosiac Recombinant

Introduction:
Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).

Description:
The E.Coli derived recombinant mosiac protein contains the gp21 and gp46 immunodominant regions, 374-400 amino acids and 190-207 amino acids.

Purification Method:
HTLV-1 Mosaic was purified by proprietary chromatographic technique.

Purity:
HTLV-1 Mosaic protein is >95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.

Formulation:
25mM Tris-HCl, 5mM glutathione and 50% glycerol.

Storage:
HTLV-1 Mosaic protein is shipped at ambient temperature. Upon arrival, Store at
-20°C.

Stability:
Five years frozen. One month in solution at room temperature.

Specificity:
Immunoreactive with all sera of HTLV-I and HTLV-II infected individuals with antibody response to HTLV envelope.

Applications: 
HTLV-1 Mosaic can be used as an antigen in ELISA and Western Blots. Excellent reagent for correct detection of HTLV infections, with minimal specificity problems.

Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.