HTLV-1 + 2
HTLV-1 + 2 Recombinant

Introduction:
Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
 
Description:
E.coli derived recombinant 56 kDa protein, (Purified/Coating; EIA), strain: BL21 DE3.

Purification Method:
HTLV protein was purified by proprietary chromatographic technique.

Purity:
HTLV 1+2 protein is >95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.

Formulation:
25mM Tris, 250mM Glycine and 0.1% SDS.

Storage:
HTLV- 1+2 protein is shipped at ambient temperature. Upon arrival, Store at -20°C.

Stability:
Five years frozen. One month in solution at 40C.

Applications:
HTLV 1+2 protein can used as an antigen in ELISA and Western Blots.

Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.