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Catalogue Number
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PRO-821
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Synonyms
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HMG14, GC104230, High-Mobility Group Nucleosome Binding Domain 1.
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Introduction
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HMGN1 binds to the inner side of the nucleosomal DNA therefore changing the interaction between the DNA and the histone octamer. HMGN1 participates in the development which maintains transcribable genes in an exceptional chromatin conformation. HMGN1 inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.
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Description
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HMGN1 Human Recombinant produced in E.Coli is a single, non-glycosylated,
polypeptide chain containing 108 amino acids (1-100 a.a.) and having a molecular mass of 11.7 kDa. HMGN1 protein is fused to a 8 amino acid His-Tag at C-terminus and purified by standard chromatography.
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Source
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Escherichia Coli.
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Physical Appearance
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Sterile filtered colorless solution.
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Formulation
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HMGN1 Human solution containing 20mM Trsi HCL pH-8, 1mM DTT, 0.1M NaCl, 0.1mM PMSF & 20% glycerol.
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Stability
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HMGN1 Human although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles.
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Amino acid sequence
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MPKRKVSSAE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD LEHHHHHH.
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Purity
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Greater than 95% as determined by SDS-PAGE.
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Usage
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ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Related Products
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