HDGF Human | ProSpec

Description

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Quantity

Shipping

Hepatoma-Derived Growth Factor Human Recombinant

	5µg($50)
	20µg($130)
	1mg($3600)

Ice Packs

Catalogue Number

CYT-681

Synonyms

High-mobility group protein 1-like 2, HMG1L2, HMG-1L2, Hepatoma-derived growth factor, HDGF, FLJ96580, DKFZp686J1764.

Introduction

HDGF is a member of the hepatoma-derived growth factor family. HDGF plays a role as a secreted mitogen from the human hepatoma cell line Huh-7. HDGF is a nuclear targeted vascular smooth muscle cell mitogen as well as a heparin-binding protein that is greatly expressed in tumor cells where it stimulates proliferation. HDGF takes part in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. HDGF plays a role in the carcinogenesis of gastric epithelial cells through promotion of cell proliferation by Erk1/2 activation. HDGF is linked with tumorigenesis and the growth of cancer. HDGF is a self-regulating factor connected with the prognosis of liver cancer, non-small cell lung cancer and pancreatic cancer. HDGF has proliferative, angiogenic, and neurotrophic activity. HDGF is a distinctive nuclear targeting growth factor that is vastly expressed in HCC cells and is a prognostic factor for HCC.

Description

The HDGF Human recombinant protein is a single, non-glycosilated polypeptide chain produced in E. coli, having a molecular weight of 11.5kDa and containing 100 amino acids.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

The HDGF protein solution is formulated in 20mM Tris-HCl pH-7.5 1mM DTT, 10% glycerol and 1mM EDTA.

Amino Acid Sequence

MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY.

Purity

Greater than 95% as determined by SDS-PAGE.

Storage

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.