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Protein Catalog >> Viral Antigens >> Hepatitis C >> HCV Core 22kDa
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Hepatitis C Virus Core 22kDa Recombinant
Ice Packs
Catalogue Number HCV-241
Introduction HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae.
HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).
Description The E.coli derived recombinant protein contains the HCV core nucleocapsid genotype 1b, immunodominant regions, amino acids 2-192, 22kDa.
The protein is fused with b-galactosidase (114 kDa) at N-terminus.
Purification Method HCV-Core protein was purified by proprietary chromatographic technique.
Purity HCV-Core Protein is >95% pure as determined by 10% PAGE (coomassie staining).
Formulation 20mM Tris HCl pH-8, 8M urea and 10mM b-mercaptoethanol.
Sequence mstnpkpqrk tkrntnrrpq dvkfpgvgqi vggvyllprr gprlgvratr ktsersqprg rrqpipkarr pegrtwaqpg ypwplygneg cgwagwllsp rgsrpswgpt dprrrsrnlg kvidtltcgf adlmgyiplv gaplggaara lahgvrvled gvnyatgnlp gcsfsiflla llscltvpa.
Storage HCV-Corealthough stable at 4°C for 1 week, should be stored below -18°C.
Please prevent freeze thaw cycles.
Specificity Immunoreactive with sera of HCV-infected individuals.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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» HCV Genotype 1b, 170 a.a.
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