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Catalogue Number
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ANT-410
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Synonyms
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G protein pathway suppressor 2, GPS-2, GPS2, AMF-1, MGC104294, MGC119287, MGC119288, MGC119289.
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Type
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Mouse Anti Human Monoclonal.
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Introduction
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GPS2 is a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, GPS2 could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of the GPS2 may be signal repression. GPS2 is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.
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Clone
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P1E2AT.
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Immunogen
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Anti-human GPS2 mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GPS2 amino acids 161-311 purified from E. coli.
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Ig Subclass
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Mouse IgG3 heavy chain and κ light chain.
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Purification Method
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GPS2 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
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Protein formulation
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1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
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Storage Procedures
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For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C.
Prevent freeze thaw cycles.
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Stability / Shelf Life
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12 months at -20°C. 1 month at 4°C.
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Applications
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GPS2 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.
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Usage
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ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Related Products
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Ness-Ziona, 74140 Israel
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Website : www.prospecbio.com
Email: info@prospecbio.com |
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