Dengue Envelope 3 ST4

Description

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Dengue Virus Subtype 4 Envelope 15kDa, C-Terminal (Domain III) Recombinant

	100µg($150)
	500µg($600)
	1000µg($1200)

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Catalogue Number

DEN-012

Introduction

Caused by one of four closely related virus serotypes of the genus Flavivirus, family Flaviviridae, each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. In cell culture experiments and mice Morpholino antisense oligos have shown specific activity against Dengue virus.

Description

The E.coli derived recombinant 12kDa protein is genetically engineered peptide which is derived from Dengue Type-2 envelope III domain immunodeterminant regions. The expressed dengue envelope Type-2 III domain peptide has 100 amino acids covering domain III region from amino acids 300-400, and is fused with a 6 His Tag. This peptide is particularly important for diagnostic and vaccine development as it contains multiple serotypes, neutralizing epitopes and receptor binding domain.

Method

Purified by proprietary chromatographic technique.

Purity

Protein is >95% pure as determined by 10% PAGE (coomassie staining).

Formulation

50mM sodium chloride-phosphorous buffer, pH-7.4.

Storage

Dengue Envelope-ST4 D-III although stable at 4°C for 1 week, should be stored below -18°C.
Please prevent freeze thaw cycles.

Applications

Each laboratory should determine an optimum working titer for use in its particular application.

Sequence

SYTMCSGKFSIDKEMAETQHGTTVVKVKYEGAGAPCKVPIEIRDVNKEKV
VGRIISSTPFAEYTNSVTNIELEPFGDSYIVIGVGDSALTLHWFRKGSSIV.

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.