CTLA-4 Antibody
CTLA-4 (CD152), Hamster Anti-Mouse

Synonyms:
GSE, CD152, IDDM12, CELIAC3, CTLA-4.

Type:
Hamster Anti Mouse Monoclonal

Introduction:
CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Clone:
RYNmCTLA-4

Immunogen:
mixture of mouse activated T cells

Purification Method:
Ion exchange column

Protein concentration:
1mg/ml in PBS (after reconstitution)

Storage Procedures:
Lyophilized: store at 4^oC. After reconstitution, if not intended for use within a month, aliquot and store at -20^oC.

Reconstitution:
Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

Stability / Shelf Life:
Two years lyophilized, one month in solution at 4^oC.

Antibody Properties:
Blocking and staining antibody. For staining, use for blocking CTLA-4 function should be determined by the investigator.

Available Conjugates:
This antibody is only available as purified antibody.

Usage:
Prospec's products are furnished for LABORATORY ESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.