CD11a Antibody
CD11a (LFA-1), Rat Anti-Mouse

Synonyms:
Integrin, alpha L, CD11A, p180, alpha polypeptide, ITGAL, LFA-1, LFA1A

Type:
Rat Anti Mouse Monoclonal

Introduction:
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.

Clone:
mCD11a

Immunogen:
Enriched mouse peritoneal macrophages

Ig Subclass:
Rat IgG2b

Purification Method:
Ion exchange column

Protein concentration:
1mg/ml in PBS (after reconstitution)

Storage Procedures:
Lyophilized: store at 4^oC. After reconstitution, if not intended for use within a month, aliquot and store at -20^oC.

Reconstitution:
Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

Stability / Shelf Life:
Two years lyophilized, one month in solution at 4^oC.

Antibody Properties:
Staining and blocking antibody. For staining, use 10 µl/10⁶ cells. This antibody will block signaling through the CD11a molecule. Titer for blocking should be determined by the investigator.

Usage:
Prospec's products are furnished for LABORATORY ESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.