Beta-Synuclein Human
Beta-Synuclein Human Recombinant

Synonyms:
Beta-synuclein, SNCB, β-Synuclein.

Introduction:
b-synuclein (amino acids 1-134), an acidic neuronal protein of 134 amino acids, is extremely heat-resistant. b-synucelin also has a chaperone-like activity. Recently, b-synuclein has been suggested to inhibit a-synuclein aggregation. b and a-synuclein are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease.

Description:
Recombinant Human b-Synuclein produced in E.Coli is a single,non-glycosylated polypeptide chain having a molecular mass of 14,287 Dalton.
The Recombinant Human b-Synuclein is purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Physical Appearance:
Sterile filtered colorless solution.

Formulation:
The protein (1mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 0.1M NaCl and 1mM MgCl₂.

Stability:
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Purity:
Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Amino Acid Sequence:
dvfmkglsm akegvvaaae ktkqgvteaa ektkegvlyv gsktregvvq gvasvaektk eqashlggav fsgagniaaa tglvkreefp tdlkpeevaq eaaeepliep lmepegesye dppqeeyqey epea

Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.