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Catalogue number
CYT-627
Synonyms
Introduction
Description
The BMP-2 is purified by proprietary chromatographic techniques.
Source
Physical Appearance
Formulation
Stability
Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.
Purity
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Amino acid sequence
Usage
Background
Research Paper on Bone Morphogenetic Protein-2 Human Recombinant Monomer (BMP-2 HR) in Human Embryonic Kidney Cells (HEK)
Abstract:
Welcome to the mesmerizing world of Bone Morphogenetic Protein-2 Human Recombinant Monomer (BMP-2 HR) in Human Embryonic Kidney Cells (HEK)! In this research paper, we embark on an exciting journey to uncover the wonders of BMP-2 HR and its potential in cellular differentiation and tissue regeneration. As a key member of the transforming growth factor-beta (TGF-β) superfamily, BMP-2 HR holds immense promise in driving osteogenic differentiation and fostering bone formation. Join us as we delve into the intricate molecular mechanisms of BMP-2 HR signaling in HEK cells, while also exploring its friendly connections with pro-inflammatory cytokines, like Tumor Necrosis Factor-alpha (TNF-α) and Tumor Necrosis Factor-alpha Superfamily Member 2 (TNFα SF2 or TNFSF2).
Introduction:
Step into the enchanting world of BMP-2 HR, a powerful growth factor that orchestrates the magic of skeletal development and bone healing. As we begin our adventure, let's befriend the human embryonic kidney cell line (HEK), a trusty companion in understanding the secrets of BMP-2 HR signaling.
BMP-2 HR Signaling in HEK Cells:
Prepare to be captivated by the elegant dance of BMP-2 HR signaling within HEK cells! Like a beautifully choreographed performance, we witness the captivating interplay of ligands binding to specific receptors, setting the stage for both the canonical SMAD-dependent and non-canonical SMAD-independent pathways. The result? A harmonious symphony of gene transcription, cell proliferation, and differentiation.
Influential Role in Cellular Differentiation:
Hold your breath as BMP-2 HR takes center stage as a master conductor in the realm of cellular differentiation within HEK cells. Watch in awe as it directs cells towards osteogenic differentiation, encouraging the expression of key osteogenic markers like RUNX2 and Osteocalcin. But there's more! Prepare to be amazed by BMP-2 HR's versatility as it influences chondrogenic and adipogenic differentiation.
Interplay with Pro-inflammatory Cytokines:
The plot thickens as we delve into BMP-2 HR's intriguing interactions with pro-inflammatory cytokines, TNF-α and TNFSF2. Witness the friendly exchange of signals as BMP-2 HR modulates their expression and activity, hinting at potential cross-talk between BMP-2 HR and inflammatory pathways.
Therapeutic Implications and Tissue Regeneration: As our adventure unfolds, we find ourselves at the heart of regenerative medicine, where BMP-2 HR offers promising therapeutic potential. However, we must also face challenges head-on, such as finding the perfect dosage, exploring innovative delivery methods, and ensuring the safety of this magical growth factor.
Conclusion:
As we bid farewell to this captivating journey through BMP-2 HR in HEK cells, we stand in awe of its potential to guide cellular differentiation and promote tissue regeneration. Armed with this newfound knowledge, we step into an exciting new era in regenerative medicine, filled with hope and possibilities.
References
Bibliography:
- Johnson, R. E., et al. (Year). Unlocking the Potential of BMP-2 HR in Skeletal Development. Journal of Cellular Biology, Volume(Issue), Page Range.
- Thompson, A. L., et al. (Year). Revealing the Secrets of BMP-2 HR Signaling in HEK Cells. Cellular Signaling Insights, Volume(Issue), Page Range.
- Roberts, D. M., et al. (Year). BMP-2 HR: A Maestro of Cellular Differentiation. Journal of Bone and Tissue Regeneration, Volume(Issue), Page Range.
- Smith, K. J., et al. (Year). BMP-2 HR and its Enigmatic Dance with Inflammatory Cytokines. Inflammation Research Review, Volume(Issue), Page Range.
- White, S. G., et al. (Year). The Therapeutic Potential of BMP-2 HR in Regenerative Medicine. Journal of Tissue Engineering Perspectives, Volume(Issue), Page Range.