- Name
- Description
- Cat#
- Pricings
- Quantity
Catalogue number
CYT-261
Synonyms
Introduction
Description
The BMP-2 is purified by proprietary chromatographic techniques.
Source
Physical Appearance
Formulation
Solubility
Stability
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Amino acid sequence
Biological Activity
Protein content
1. UV spectroscopy at 280 nm using the absorbency value of 1.4 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
2. Analysis by RP-HPLC, using a standard solution of BMP-2 as a Reference Standard.
Usage
Safety Data Sheet
References
Title:β-Catenin Signaling Pathway Is Crucial for Bone Morphogenetic Protein 2 to Induce New Bone Formation.
Publication:First Published on November 3, 2006, doi: 10.1074/jbc.M602700200 January 5, 2007 The Journal of Biological Chemistry, 282, 526-533.
Link:BMP 2 prospec publication
Background
BMP-2 Bone Morphogenetic Protein-2 Human Recombinant: Insights into its Significance in Development, Regeneration, and Disease
Abstract:
BMP-2 (Bone Morphogenetic Protein-2), also known as BMP-2A, is a potent growth factor that plays a crucial role in various biological processes, including embryonic development, tissue regeneration, and disease progression.
This research paper aims to comprehensively explore the molecular characteristics, signaling pathways, and diverse physiological functions of BMP-2. Additionally, it investigates the therapeutic implications of BMP-2 in different disorders.
Synonyms such as BMP-2 and BMP2A associated with the protein are discussed throughout the paper to highlight their relevance in scientific literature.
Introduction:
BMP-2, also known as BMP-2A, is a growth factor with multifaceted roles in development, regeneration, and disease. This section introduces BMP-2 and its synonyms, highlighting their significance and relevance in scientific research.
Molecular Characteristics of BMP-2 :
This section explores the molecular characteristics of BMP-2, including its primary amino acid sequence, protein structure, post-translational modifications, and binding partners. The importance of these factors in determining BMP-2's biological activity and receptor specificity is discussed.
Signaling Pathways Activated by BMP-2:
BMP-2 activates specific signaling pathways upon binding to its receptors, leading to diverse cellular responses. This section focuses on the canonical BMP signaling pathway, highlighting the activation of Smad-dependent and Smad-independent pathways. The downstream effectors and transcriptional regulators involved in mediating BMP-2's cellular responses are also discussed.
Physiological Functions of BMP-2:
BMP-2 plays critical roles in various physiological processes, including embryonic development, skeletal development, tissue regeneration, and homeostasis. This section provides an in-depth analysis of BMP-2's contributions to these processes, emphasizing its role in cell differentiation, proliferation, migration, and extracellular matrix remodeling.
Therapeutic Implications of BMP-2:
The unique properties of BMP-2 make it a promising therapeutic candidate for various disorders. This section discusses the potential applications of BMP-2 in bone regeneration, spinal fusion, non-union fractures, and periodontal regeneration. The challenges and future directions in utilizing BMP-2 as a therapeutic agent are also explored.
BMP-2 in Disease Progression:
BMP-2 is implicated in the progression of certain diseases, including cancer, cardiovascular disorders, and fibrosis. This section examines the role of BMP-2 in tumor growth, angiogenesis, cardiac remodeling, and tissue fibrosis. The therapeutic implications and targeting of BMP-2 in disease management are also discussed.
Conclusion:
BMP-2, also known as BMP-2A, is a critical growth factor involved in development, regeneration, and disease progression. Understanding the molecular characteristics, signaling pathways, and physiological functions of BMP-2 contributes to the exploration of its therapeutic potential in various disorders.